Hospital del Mar Institut d'Investigacions Mèdiques

August 29, 2013 – 01:54
Doctors Sift Through Patients Genomes To Solve Medical Mysteries

Important progress in the fight against skin cancer

Researchers from the Institute Hospital del Mar Medical Research (IMIM) led by Luis Espinosa have identified a new function key IkBa protein in developing a type of skin cancer, squamous cell carcinoma. The study, published in the journal Cancer Cell, provides a new diagnostic tool for the disease and, in the future, will identify therapeutic targets to treat this cancer.

Until now, it was known the IkBa protein function in the cytoplasm where it inhibits NFkB pathway, a protein complex involved in cell immune response. We have now discovered that in the core of keratinocytes, the cells typical of the skin, and in the nucleus of fibroblasts, there is a different way of IkBa result of binding to another molecule called Sumo (resulting Sumo-protein IkBa that had been previously identified by other groups but it was unknown what his role.

Read more about "Important progress in the fight against skin cancer"

Source: www.imim.es

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Patient-Centered Outcomes Research Institute,

2011-12-28 10:30:09 by jimmymac60

It's been in there all along and alreadt enacted..
A non-profit Patient-Centered Outcomes Research Institute is established, independent from government, to undertake comparative effectiveness research. This is charged with examining the "relative health outcomes, clinical effectiveness, and appropriateness" of different medical treatments by evaluating existing studies and conducting its own. Its 19-member board is to include patients, doctors, hospitals, drug makers, device manufacturers, insurers, payers, government officials and health experts. It will not have the power to mandate or even endorse coverage rules or reimbursement for any particular treatment

Patient-Centered Outcomes Research Institute...

2011-12-28 10:32:12 by jimmymac60

Effective at enactment of Patient Protection and Affordable Care Act
A non-profit Patient-Centered Outcomes Research Institute is established, independent from government, to undertake comparative effectiveness research. This is charged with examining the "relative health outcomes, clinical effectiveness, and appropriateness" of different medical treatments by evaluating existing studies and conducting its own. Its 19-member board is to include patients, doctors, hospitals, drug makers, device manufacturers, insurers, payers, government officials and health experts. It will not have the power to mandate or even endorse coverage rules or reimbursement for any particular treatment

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